CDK5 and ABL1 enzyme substrate 1/2 (IPR012388)

Short name: CABLES1/2

Overlapping homologous superfamilies


Family relationships



This group represents protein CABLES (CDK5 and ABL1 enzyme substrate), including CABLES1 and CABLES2 [PMID: 14729625, PMID: 10896159]. CABLES1 is a cyclin-dependent kinase binding protein, primarily involved in cell cycle regulation [PMID: 18059193]. CABLES1 binds to different functional domains of p53 and p73 and modifies their cell death-inducing activities [PMID: 11706030]. It may be a tumour suppressor in human ovarian cancer [PMID: 18059193]. CABLES2 is involved in both p53-mediated and p53-independent apoptotic pathways [PMID: 14637168].

GO terms

Biological Process

GO:0051726 regulation of cell cycle

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.