Endopolyphosphatase, Ppn1p-related (IPR012358)

Short name: EndopolyPtase_N1

Overlapping homologous superfamilies


Family relationships



Endopolyphosphatases are enzymes that hydrolyse long inorganic phosphate chains to shorter chains of (predominantly) 60 or 3 phosphate units. The Saccharomyces cerevisiae (Baker's yeast) member, Ppn1p, is an essential vacuolar enzyme [PMID: 11447286]. It is a homodimer of chains of about 350 amino acids derived by proteolysis, from the amino end, of the precursor sequence. This region contains the metallophosphoesterase domain, which is found in a large number of proteins with phosphoesterase activity.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0000298 endopolyphosphatase activity

Cellular Component

GO:0016021 integral component of membrane
GO:0005773 vacuole

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.