Four-helical cytokine, core (IPR012351)

Short name: 4_helix_cytokine_core

Domain relationships


This entry represents a 4-helical bundle domain found predominantly in long- and short-chain cytokines, such as interleukins, interferons, growth hormones, and granulocyte colony stimulating factors. Cytokines play a crucial role in the development of an immune response by organising the recruitment and trafficking of immune cell populations throughout the body, usually through GPCR signalling [PMID: 12466283]. Most cytokines have a predominantly alpha helical structure, and share a core domain consisting of a closed bundle of four helices in a left-handed twist, with two crossover connections [PMID: 9118960].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.