Domain

p53/RUNT-type transcription factor, DNA-binding domain (IPR012346)

Short name: p53/RUNT-type_TF_DNA-bd

Domain relationships

Description

This DNA-binding domain is found in the p53 and the RUNT families of transcription factors. The DNA-binding domain acts to clamp or encircle the DNA target in order to stabilise the protein-DNA complex. This domain has an immunoglobulin-like fold consisting of a beta-sandwich of 9 strands in two sheets with a Greek key topology [PMID: 10545320].

The p53 tumour suppressor functions primarily as a sequence-specific transcription factor, but also has transcription-independent roles in DNA repair and recombination [PMID: 15688066]. In addition, p53, as well as its family members p63 and p73, are involved in the survival/death checkpoint in peripheral and central neurons, where full-length proteins appear to be involved in cell death, and truncated isoforms that retain the DNA-binding domain are involved in cell survival [PMID: 15359011].

RUNT domain (RD) proteins (also known as RUNX, AML, CBF-alpha and PEBP2-alpha) are a family of transcription factors involved in various developmental pathways. The RD has two general functions: it directs the binding of the protein to a target sequence, PyGPyGGTPy (Py=pyrimidine), in order to regulate the expression of target genes; and it mediates protein-protein interactions with CBF-beta which modulates the DNA-binding affinity of the RD [PMID: 15735333].

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
GENE3D