p53/RUNT-type transcription factor, DNA-binding domain superfamily (IPR012346)
Short name: p53/RUNT-type_TF_DNA-bd_sf
- Acute myeloid leukemia 1 protein (AML1)/Runt (IPR000040)
- p53 tumour suppressor family (IPR002117)
- p53-like transcription factor, DNA-binding (IPR008967)
- p53, DNA-binding domain (IPR011615)
- Runt domain (IPR013524)
- Runt-related transcription factor RUNX (IPR016554)
- Tumour protein p63 (IPR032645)
- Tumour protein p73 (IPR032646)
This DNA-binding domain superfamily is found in the p53 and the RUNT families of transcription factors. The DNA-binding domain acts to clamp or encircle the DNA target in order to stabilise the protein-DNA complex. This domain has an immunoglobulin-like fold consisting of a beta-sandwich of 9 strands in two sheets with a Greek key topology [PMID: 10545320].
The p53 tumour suppressor functions primarily as a sequence-specific transcription factor, but also has transcription-independent roles in DNA repair and recombination [PMID: 15688066]. In addition, p53, as well as its family members p63 and p73, are involved in the survival/death checkpoint in peripheral and central neurons, where full-length proteins appear to be involved in cell death, and truncated isoforms that retain the DNA-binding domain are involved in cell survival [PMID: 15359011].
RUNT domain (RD) proteins (also known as RUNX, AML, CBF-alpha and PEBP2-alpha) are a family of transcription factors involved in various developmental pathways. The RD has two general functions: it directs the binding of the protein to a target sequence, PyGPyGGTPy (Py=pyrimidine), in order to regulate the expression of target genes; and it mediates protein-protein interactions with CBF-beta which modulates the DNA-binding affinity of the RD [PMID: 15735333].
- G3DSA:22.214.171.1240 (G3DSA:126.96.36.1990)