Homologous Superfamily

Ribonuclease H-like superfamily (IPR012337)

Short name: RNaseH-like_sf

Description

The catalytic domain of several polynucleotidyl transferases share a similar structure, consisting of a 3-layer alpha/beta/alpha fold that contains mixed beta sheets, suggesting that they share a similar mechanism of catalysis. Polynucleotidyl transferases containing this domain include ribonuclease H class I (RNase HI) and class II (RNase HII), HIV RNase (reverse transcriptase domain), retroviral integrase (catalytic domain), Mu transposase (core domain), transposase inhibitor Tn5 (containing additional all-alpha subdomains), DnaQ-like 3'-5' exonucleases (exonuclease domains), RuvC resolvase, and mitochondrial resolvase ydc2 (catalytic domain) [PMID: 15299518, PMID: 8696976, PMID: 12823554].

This superfamily also includes the YqgF domain, described as RNase H-like and typified by the Escherichia coli protein YqgF [PMID: 14512736, PMID: 10982859]. YqgF domain-containing proteins are predicted to be ribonucleases or resolvases based on homology to RuvC Holliday junction resolvases.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
SUPERFAMILY