Stonin homology (IPR012320)

Short name: SHD_dom

Overlapping homologous superfamilies


Domain relationships



Human stonins, like their Drosophila homologue stoned B, are supposed to be endocytotic proteins involved in clathrin-mediated endocytosis at synapses. The two human stonins, as well as their Drosophila melanogaster (Fruit fly) and Caenorhabditis elegans homologues, exhibit a modular structure consisting of an N-terminal proline- and serine-rich domain, a central stonin homology domain (SHD), and a C-terminal domain homologous to the signal-binding domain of the mu subunits of adaptor protein (AP) complexes (mu-homology domain). The ~140 amino-acid SHD domain has not been described in other proteins and may thus be unique to members of the stonin family. Its function is not yet known [PMID: 11381094, PMID: 14726597].

GO terms

Biological Process

GO:0006897 endocytosis

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles