KASH domain (IPR012315)

Short name: KASH

Overlapping homologous superfamilies


Domain relationships



The KASH (Klarsicht/ANC-1/Syne-1 homology), or KLS domain is a highly hydrophobic nuclear envelope localization domain of approximately 60 amino acids comprising a 20-amino-acid transmembrane region and a 30-35-residue C-terminal region that lies between the inner and the outer nuclear membranes. The KASH domain is found in association with other domains, such as spectrin repeats and CH, at the C terminus of proteins tethered to the nuclear membrane in diverse cell types [PMID: 10556085, PMID: 10878022, PMID: 12169658, PMID: 12408964, PMID: 15579692].

Some proteins known to contain a KASH domain are listed below:

  • Caenorhabditis elegans nuclear anchorage protein 1 (ANC-1).
  • Drosophila Klarsicht (Klar), a protein associated with nuclei and required for a subset of nuclear migrations.
  • Drosophila MSP-300.
  • Vetebrate nesprin-1, -2, -3 and -4 (also known as Syne1-4). They are components of the linker of the nucleoskeleton and cytoskeleton (LINC) complex, which plays critical roles in nuclear positioning, cell polarisation and cellular stiffness [PMID: 22945352].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles