Pathways & interactions
TBP domain superfamily (IPR012295)
Short name: TBP_dom_sf
- Clathrin adaptor, alpha-adaptin, appendage, C-terminal subdomain (IPR003164)
- Coatomer/calthrin adaptor appendage, C-terminal subdomain (IPR009028)
- Beta-adaptin appendage, C-terminal subdomain (IPR015151)
- TATA-Box binding protein-like (IPR015445)
- Ribonuclease HIII, N-terminal (IPR024568)
- Coatomer subunit gamma, C-terminal (IPR032154)
- TATA-box binding protein, eukaryotic (IPR033710)
The TATA-box binding protein (TBP) is required for the initiation of transcription by RNA polymerases I, II and III, from promoters with or without a TATA box [PMID: 12782648, PMID: 10974559]. The core of TBP (~180 residues) is highly conserved and contains two 77-amino acid repeats that produce a saddle-shaped structure that straddles the DNA; this region binds to the TATA box, and interacts with transcription factors and regulatory proteins [PMID: 1436073].
TBP shares structural similarity with the C-terminal of beta(2)-adaptin, which is one of four subunits that comprise the clathrin adaptor. This structure can also be found in the N terminus of RNase H3. The N terminus of RNase H3 is suggested to be a substrate binding domain [PMID: 21664908].
- G3DSA:3.30.310.10 (G3DSA:3.30.310.10)