Homologous Superfamily

RNA polymerase subunit, RPB6/omega (IPR012293)

Short name: RNAP_RPB6_omega

Overlapping entries


Prokaryotes contain a single RNA polymerase (RNAP) that is responsible for the transcription of all genes, while eukaryotes have three classes of RNAPs (I-III) with specific transcriptional roles. In eukaryotes, the RPB6 subunit (also known as RPABC2) is common to all three polymerases. RPB6 is involved in the initiation of transcription. Bacterial DNA-dependent RNAP contains a small subunit termed omega, where the complete RNAP composition is beta'-beta-alpha(I)-alpha(II)-omega. The bacterial omega subunit is homologous in sequence and structure to the eukaryotic RPB6 subunit; they also have similar functional roles, being able to promote RNA polymerase assembly, possibly through a latching mechanism [PMID: 11158566].

GO terms

Biological Process

GO:0006351 transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.