Semialdehyde dehydrogenase, dimerisation domain (IPR012280)
Short name: Semialdhyde_DH_dimer_dom
Overlapping homologous superfamilies
This domain contains N-acetyl-glutamine semialdehyde dehydrogenase (AgrC), which is involved in arginine biosynthesis, and aspartate-semialdehyde dehydrogenase [PMID: 10369777], an enzyme involved in the biosynthesis of various amino acids from aspartate. It also contains the yeast and fungal Arg5,6 protein, which is cleaved into the enzymes N-acety-gamma-glutamyl-phosphate reductase and acetylglutamate kinase. These are also involved in arginine biosynthesis. All proteins in this entry contain a dimerisation domain of semialdehyde dehydrogenase.
GO:0003942 N-acetyl-gamma-glutamyl-phosphate reductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0046983 protein dimerization activity
- PF02774 (Semialdhyde_dhC)