CCR4-NOT complex, subunit 3/ 5 (IPR012270)

Short name: CCR4-NOT_su3/5

Overlapping homologous superfamilies


Family relationships



The Ccr4-Not complex is a global regulator of gene expression that is conserved from yeast to human. It affects genes positively and negatively and is thought to regulate transcription factor IID function. In Saccharomyces cerevisiae, it exists in two prominent forms and consists of at least nine core subunits: the five Not proteins (Not1p to Not5p), Caf1p, Caf40p, Caf130p and Ccr4p [PMID: 10637334]. The Ccr4-Not complex regulates many different cellular functions, including RNA degradation and transcription initiation. It may be a regulatory platform that senses nutrient levels and stress [PMID: 12957374]. Caf1p and Ccr4p, are directly involved in mRNA deadenylation, and Caf1p is associated with Dhh1p, a putative RNA helicase thought to be a component of the decapping complex [PMID: 11696541]. Pop2, a component of the Ccr4-Not complex, functions as a deadenylase [PMID: 18430587].

This group represents a CCR4-NOT complex, subunits 3 and 5.

GO terms

Biological Process

GO:0006355 regulation of transcription, DNA-templated

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0030015 CCR4-NOT core complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.