Peptidase S1A, acrosin (IPR012267)

Short name: Pept_S1A_acrosin

Overlapping homologous superfamilies

Family relationships


This group of proteins are serine peptidases belonging to MEROPS peptidase family S1, subfamily S1A (chymotrypsin, clan PA(S)). Members of this family are found specifically within the acrosomal vesicle of all mammalian spermatozoa. Acrosin is thought to be involved in the recognition and binding of the sperm to the zona pellucida of the ovum and the sperm penetration through the zona pellucida. Mouse knock-out mutants suggest that Acr- sperm have a selective disadvantage when they are in competition with Acr+ sper [PMID: 9041140].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004252 serine-type endopeptidase activity

Cellular Component

GO:0001669 acrosomal vesicle

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.