Family

Protein kinase C (IPR012233)

Short name: PKC

Family relationships

None.

Description

This group represents protein kinase C (KPC), including zeta/iota types from mammals, protein kinase C-like 3 from round worms [PMID: 9422779] and atypical protein kinase C (aPKC) from fruit flies [PMID: 10995441].

Protein kinase C iota type (PRKCI) is a calcium- and diacylglycerol-independent serine/ threonine-protein kinase that plays a general protective role against apoptotic stimuli, is involved in NF-kappa-B activation, cell survival, differentiation and polarity, and contributes to the regulation of microtubule dynamics in the early secretory pathway [PMID: 10467349, PMID: 11544035, PMID: 11257119]. It is an indirect co-regulator of the stress-activated transcription factor HSF1 and the heat shock response [PMID: 20686607]. It has been linked to cancers [PMID: 19738040, PMID: 22349825].

Protein kinase C zeta type is a calcium- and diacylglycerol-independent serine/threonine-protein kinase that functions in phosphatidylinositol 3-kinase (PI3K) pathway and mitogen-activated protein (MAP) kinase cascade, and is involved in NF-kappa-B activation, mitogenic signaling, cell proliferation, cell polarity, inflammatory response and maintenance of long-term potentiation (LTP) [PMID: 11035106].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0005524 ATP binding
GO:0004674 protein serine/threonine kinase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF