Peptidase S1A, coagulation factor VII/IX/X/C/Z (IPR012224)

Short name: Pept_S1A_FX

Overlapping homologous superfamilies

Family relationships


This group of plasma glycoproteins includes coagulation factors VII, IX, and X, and proteins C and Z, which belong to MEROPS peptidase family S1, subfamily S1A (chymotrypsin, clan PA(S)). All but protein Z are peptidases and are involved in blood coagulation. The precursors contain a signal sequence, propeptide, Gla domain, two EGF domains (although sometimes only one is detected by Pfam), and a trypsin domain. Except for protein Z, they are further cleaved between the second EGF domain and the trypsin domain into light and heavy chains, which are connected by a disulphide bond. Glutamic acid residues in the Gla domain undergo vitamin K-dependent carboxylation, allowing this region to bind calcium and membrane phospholipid [PMID: 8663165]. The propeptide region is important in providing a recognition site for the gamma-carboxylase [PMID: 10358041]. Typically one aspartic acid residue in the light chain is post-translationally modified to erythro-beta-hydroxyaspartic acid [PMID: 6688526, PMID: 6630196].

GO terms

Biological Process

GO:0007596 blood coagulation

Molecular Function

GO:0005509 calcium ion binding
GO:0004252 serine-type endopeptidase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.