Replication factor C subunit 1 (IPR012178)

Short name: RFC1

Overlapping homologous superfamilies

Family relationships



This entry represents replication factor C subunit 1 (RFC1), which is the large subunit of replication factor C (RF-C), a five subunit DNA polymerase accessory protein. RF-C is a DNA binding protein complex and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon [PMID: 14530260]. It also may have a role in telomere stability [PMID: 8954124].

GO terms

Biological Process

GO:0006281 DNA repair
GO:0006260 DNA replication

Molecular Function

GO:0005524 ATP binding
GO:0003677 DNA binding
GO:0003689 DNA clamp loader activity

Cellular Component

GO:0005663 DNA replication factor C complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.