Fatty acid desaturase (IPR012171)

Short name: Fatty_acid_desaturase

Overlapping homologous superfamilies


Family relationships



This entry includes fatty acid desaturase family members from bacteria, fungi, plants and animals. Proteins in this family contain the fatty acid desaturase domain (IPR005804). The eukaryotic members, including human FADS1 and FADS2, are fusion proteins containing an N-terminal cytochrome b5-like domain and a C-terminal multiple membrane-spanning desaturase portion [PMID: 10860662].

Three human fatty acid desaturase genes have been identified, acid desaturase 1-3 (FADS1-3). FADS1 and FADS2 encode delta-5 desaturase (D5D) and delta-6 desaturase (D6D) respectively. They are membrane-bound enzymes that catalyse the rate-limiting formation of endogenous long-chain polyunsaturated fatty acid (PUFA). The function of the FADS3 product is not clear [PMID: 25123259].

GO terms

Biological Process

GO:0006629 lipid metabolic process

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.