Family

Histidinol dehydrogenase (IPR012131)

Short name: Hstdl_DH

Family relationships

Description

Histidinol dehydrogenase (HDH) catalyzes the terminal step in the biosynthesis of histidine in bacteria, fungi, and plants, the four-electron oxidation of L-histidinol to histidine.

In 4-electron dehydrogenases, a single active site catalyses 2 separate oxidation steps: oxidation of the substrate alcohol to an intermediate aldehyde; and oxidation of the aldehyde to the product acid, in this case His [PMID: 3533140]. The reaction proceeds via a tightly- or covalently-bound inter-mediate, and requires the presence of 2 NAD molecules [PMID: 3533140]. By contrast with most dehydrogenases, the substrate is bound before the NAD coenzyme [PMID: 3533140]. A Cys residue has been implicated in the catalytic mechanism of the second oxidative step [PMID: 3533140].

In bacteria HDH is a single chain polypeptide; in fungi it is the C-terminal domain of a multifunctional enzyme which catalyzes three different steps of histidine biosynthesis; and in plants it is expressed as nuclear encoded protein precursor which is exported to the chloroplast [PMID: 2034659].

GO terms

Biological Process

GO:0000105 histidine biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0051287 NAD binding
GO:0004399 histidinol dehydrogenase activity
GO:0008270 zinc ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
CDD
HAMAP
Pfam
PANTHER
TIGRFAMs
PRINTS