DNA repair protein Rev1 (IPR012112)

Short name: REV1

Family relationships



Rev1 is a deoxycytidyl transferase involved in translesion DNA synthesis (TLS) pathway to bypass DNA lesions during replication [PMID: 23143872]. During TLS, Y-family DNA polymerase (Poleta, Polkappa, Poliota and Rev1) incorporates a nucleotide opposite the DNA lesion, and then Polzeta (consitst of Rev3 and Rev7) carries out primer extension. Rev1 is a unique member of the Y polymerase family, since its catalytic activity is limited to DNA-dependent, deoxycytidyl transferase activity [PMID: 8751446, PMID: 11711549, PMID: 11278384].

GO terms

Biological Process

GO:0006281 DNA repair
GO:0042276 error-prone translesion synthesis

Molecular Function

GO:0003684 damaged DNA binding
GO:0016779 nucleotidyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.