ADP-ribosylarginine hydrolase (IPR012108)

Short name: ADP-ribosylarg_hydro

Overlapping homologous superfamilies

Family relationships


This enzyme catalyzes the reverse reaction of mono-ADP-ribosylation by removing ADP-ribose from arginine residues in ADP-ribosylated proteins. NAD:arginine ADP-ribosyltransferases and ADP-ribosylarginine hydrolases catalyse opposing arms of the putative ADP-ribosylation cycle.

ADP-ribosylarginine hydrolases from mammalian tissues and Rhodospirillum rubrum exhibit three regions of similarity in their deduced amino acid sequence. The conserved vicinal aspartates 60 and 61 in rat ADP-ribosylarginine hydrolase are critical for catalytic activity, but not for high affinity binding of the substrate analogue, ADP-ribose [PMID: 10358013].

ADP-ribosylarginine hydrolases in different organisms also differ in their dithiothreitol (DTT) requirements. Cysteine 108 in rat hydrolase plays a critical role in DTT dependence and may be important in immunoreactivity [PMID: 8349667].

GO terms

Biological Process

GO:0051725 protein de-ADP-ribosylation

Molecular Function

GO:0003875 ADP-ribosylarginine hydrolase activity
GO:0000287 magnesium ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.