Family

Chromosome partition protein MukB (IPR012090)

Short name: MukB

Family relationships

None.

Description

MukB is a 170kDa protein that is involved in ATP-dependent chromosome partitioning during cell division in Escherichia coli [PMID: 10545328, PMID: 9688555]. Its domain structure is reminiscent of the eukaryotic motor proteins kinesin and myosin [PMID: 9688555]. MukB, like SMC (structural maintenance of chromosomes) proteins with which it shares function, has a dimeric structure and similar domain architecture [PMID: 10545328]. It is a filamentous protein with globular domains at the ends, and also having DNA binding and nucleotide binding abilitiesIt forms a homodimer with a rod-and-hinge structure with a pair of large, C-terminal globular domains at one end and a pair of small, N-terminal globular domains at the other [PMID: 1464330]. The N-terminal domain carries a putative Walker A nucleotide-binding region and the C-terminal domain has been shown to bind to DNA [PMID: 10545328].

GO terms

Biological Process

GO:0030261 chromosome condensation
GO:0007059 chromosome segregation

Molecular Function

GO:0005524 ATP binding
GO:0003677 DNA binding

Cellular Component

GO:0009295 nucleoid

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PIRSF
HAMAP