Bifunctional aldehyde-alcohol dehydrogenase (IPR012079)
Short name: Bifunc_Ald-ADH
Overlapping homologous superfamilies
- Iron-type alcohol dehydrogenase-like (IPR039697)
- Bifunctional aldehyde-alcohol dehydrogenase (IPR012079)
This enzyme has two NAD+-dependent activities: alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ACDH) [PMID: 7980441, PMID: 18726959, PMID: 6998946]. It controls ethanol and acetate production under aerobic conditions [PMID: 23201265]. The N-terminal region of the protein is highly homologous to aldehyde:NAD(+) oxidoreductases, whereas the C-terminal region is homologous to a family of Fe(2+)-dependent ethanol:NAD(+) oxidoreductases. In Escherichia coli, this fusion protein also functions as a pyruvate formate lyase deactivase [PMID: 10922373].
No terms assigned in this category.
- PIRSF000111 (ALDH_ADH)