Bifunctional aldehyde-alcohol dehydrogenase (IPR012079)

Short name: Bifunc_Ald-ADH

Overlapping homologous superfamilies

Family relationships


This enzyme has two NAD+-dependent activities: alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ACDH) [PMID: 7980441, PMID: 18726959, PMID: 6998946]. It controls ethanol and acetate production under aerobic conditions [PMID: 23201265]. The N-terminal region of the protein is highly homologous to aldehyde:NAD(+) oxidoreductases, whereas the C-terminal region is homologous to a family of Fe(2+)-dependent ethanol:NAD(+) oxidoreductases. In Escherichia coli, this fusion protein also functions as a pyruvate formate lyase deactivase [PMID: 10922373].

GO terms

Biological Process

GO:0006066 alcohol metabolic process
GO:0015976 carbon utilization
GO:0055114 oxidation-reduction process

Molecular Function

GO:0008774 acetaldehyde dehydrogenase (acetylating) activity
GO:0004022 alcohol dehydrogenase (NAD) activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.