D-tagatose-bisphosphate aldolase, non-catalytic subunit GatZ/KbaZ (IPR012062)

Short name: TagBP_ald_GatZ/KbaZ

Overlapping homologous superfamilies

Family relationships


Escherichia coli and other enteric bacteria contain two closely related D-tagatose 1,6-bisphosphate (TagBP)-specific aldolases involved in catabolism of galactitol (genes gatY gatZ) and of N-acetyl-galactosamine and D-galactosamine (genes kbaY, kbaZ, also called agaY, agaZ). The catalytic subunits GatY/KbaY alone are sufficient to show aldolase activity and contain most or all of the residues that have been identified as essential in substrate/product recognition and catalysis for class II aldolases [PMID: 11976750, PMID: 8955298]. However, these aldolases differ from other Class II aldolases (which are homodimeric enzymes) in that they require subunits GatZ/KbaZ for full activity and for good in vivo and in vitro stability. The Z subunits alone do not show any aldolase activity [PMID: 11976750]. It should be noted that the previous suggestion of a tagatose 6P-kinase function for AgaZ [PMID: 8932697] and other members of this family turned out to be erroneous [PMID: 10931310, PMID: 11976750].

GO terms

Biological Process

GO:0019402 galactitol metabolic process

Molecular Function

No terms assigned in this category.

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.