von Willebrand factor (IPR012011)

Short name: VWF

Family relationships



von Willebrand factor (vWF) is a multimeric adhesive protein that plays a key role in platelet function by mediating the initiation and progression of thrombus formation at sites of vascular injury [PMID: 12871266]. Binding of vWF to platelet membrane glycoprotein GPIb-alpha (PIRSF002393) of the GPIb-IX-V complex supports the arrest of bleeding after tissue trauma. The rapid association of GP1b-alpha with vWF not only initiates platelet deposition at the sites of vascular injury but is essential for maintaining thrombus growth in blood flowing at high shear rates.

GO terms

Biological Process

GO:0007596 blood coagulation
GO:0007155 cell adhesion

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005578 proteinaceous extracellular matrix

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.