Serine/threonine-protein phosphatase with EF-hands (IPR012008)

Short name: Ser/Thr-Pase_EF-hand_contain

Overlapping homologous superfamilies


Family relationships



This well-conserved family of animal EF-hand-containing serine/threonine protein phosphatases functions in diverse sensory neurons. The protein comprises an IQ calmodulin-binding region, a metallo-phosphoesterase domain (IPR004843) of the serine/threonine-specific protein phosphatase and bis(5-nucleosyl)-tetraphosphatase type, and a C-terminal extension with three calcium-binding EF-hand motifs.

The prototype protein is the product of the fruit fly rdgC gene, which is required to prevent light-induced retinal degeneration [PMID: 9326663]. There are two homologous mammalian genes, PPEF1 and PPEF2. Although no essential role has been identified, PPEF2 is expressed in retinal rod photoreceptors, where it assumes several splice forms, and in the pineal gland. PPEF1 is expressed in photosensory neurons and inner ear cells in the developing mouse [PMID: 1316807].

GO terms

Biological Process

GO:0050906 detection of stimulus involved in sensory perception

Molecular Function

GO:0005509 calcium ion binding
GO:0005506 iron ion binding
GO:0030145 manganese ion binding
GO:0004721 phosphoprotein phosphatase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.