tRNA nucleotidyltransferase, proteobacteria (IPR012006)

Short name: CCA_bact

Family relationships



This family predominantly consists of bacterial versions of tRNA adenylyltransferases. tRNA nuceotidyltransferases are responsible for the synthesis or repair of the 3' terminal CCA sequence of tRNA molecules. They are encoded by essential genes in almost all organisms and add the three ribonucleotides C, C, and A to the 3' end of tRNAs in sequential order. Most members of this family contain an additional metal dependent phosphohydrolase domain (HD). Although the precise functional role of this domain is undetermined, the demonstration in Escherichia coli of 2',3'-cyclic phosphodiesterase, 2'-nucleotidase, and phosphatase activities has led to the suggestion that it is involved in the repair of the CCA terminus [PMID: 15210699].

For additional information please see [PMID: 10075991, PMID: 12526808, PMID: 10447505, PMID: 10943560, PMID: 9868367].

GO terms

Biological Process

GO:0001680 tRNA 3'-terminal CCA addition

Molecular Function

GO:0005524 ATP binding
GO:0003723 RNA binding
GO:0004810 tRNA adenylyltransferase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.