Pyrophosphate-dependent phosphofructokinase TP0108-type (IPR012004)

Short name: PyroP-dep_PFK_TP0108

Overlapping homologous superfamilies

Family relationships


Phosphofructokinase (PFK) catalyses the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate, which then enters the Embden-Meyerhof pathway. PFK is a key regulatory enzyme in glycolysis [PMID: 11778837].

This family consists of a group of plant and bacterial pyrophosphate-dependent phosphofructokinases related to TP0108 from Treponema [PMID: 11717283]. The bacterial versions are non-allosteric dimers, while the plant versions are allosteric heterotetramers [PMID: 12015149]. They belong to the PFK domain superfamily of proteins, which also includes prokaryotic (IPR012003) and eukaryotic ATP-dependent PFKs (IPR009161). The membership of this group largely resembles group B1 PFKs [PMID: 14585511].

GO terms

Biological Process

GO:0006096 glycolytic process

Molecular Function

GO:0003872 6-phosphofructokinase activity
GO:0005524 ATP binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.