5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase (IPR011985)

Short name: DH_HpaE

Overlapping homologous superfamilies

Family relationships



This entry represents the dehydrogenase responsible for the conversion of 5-carboxymethyl-2-hydroxymuconate semialdehyde to 5-carboxymethyl-2-hydroxymuconate (a tricarboxylic acid). This is the step in the degradation of 4-hydroxyphenylacetic acid via homoprotocatechuate following the oxidative opening of the aromatic ring [PMID: 2194577].

GO terms

Biological Process

GO:1901023 4-hydroxyphenylacetate catabolic process

Molecular Function

GO:0018480 5-carboxymethyl-2-hydroxymuconic-semialdehyde dehydrogenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.