3,4-dihydroxyphenylacetate 2,3-dioxygenase (IPR011984)

Short name: HPCD

Overlapping homologous superfamilies


Family relationships



3,4-dihydroxyphenylacetate (homoprotocatechuate, hpca) 2,3-dioxygenase (HPCD) catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate. 4-hydroxyphenylacetate arises from the degradation of tyrosine. The enzyme incorporates both atoms of molecular oxygen into hpca, resulting in aromatic ring-opening to yield alpha-hydroxy-delta-carboxymethyl cis-muconic semialdehyde [PMID: 2261999, PMID: 9179284].

HPCD is a member of the class III extradiol dioxygenase family, a group of enzymes which use a non-heme Fe(II) to cleave aromatic rings between a hydroxylated carbon and an adjacent non-hydroxylated carbon.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0008687 3,4-dihydroxyphenylacetate 2,3-dioxygenase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.