FCP1-like phosphatase, phosphatase domain (IPR011947)

Short name: FCP1_euk

Overlapping homologous superfamilies

Domain relationships


This entry represents the phosphatase domain of the human RNA polymerase II subunit A C-terminal domain phosphatase (FCP1, [PMID: 15170348]) and closely related phosphatases from eukaryotes including plants, fungi [PMID: 14701811] and slime mold. This domain is a member of the haloacid dehalogenase (HAD) superfamily by virtue of a conserved set of three catalytic motifs [PMID: 7966317] and a conserved fold as predicted by PSIPRED. The third motif in this family is distinctive (hhhhDDppphW). This domain is classified as a "Class III" HAD, since there is no large "cap" domain found between motifs 1 and 2 or motifs 2 and 3 [PMID: 11601995]. This domain is related to domains found in the human NLI interacting factor-like phosphatases.

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0004721 phosphoprotein phosphatase activity

Cellular Component

GO:0005634 nucleus

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.