Domain

Predicted HAD-superfamily phosphatase, subfamily IA/Epoxide hydrolase, N-terminal (IPR011945)

Short name: HAD-SF_ppase_IA/epoxid_hydro_N

Overlapping homologous superfamilies

Domain relationships

None.

Description

This entry represents a small clade of sequences from the metazoa and bacteria. In eukaryotes, this domain exists as an N-terminal fusion to the soluble epoxide hydrolase enzyme and has recently been shown to be an active phosphatase, although the nature of the biological substrate is unclear [PMID: 12574508]. These appear to be members of the haloacid dehalogenase (HAD) superfamily of aspartate-nucleophile hydrolases by general homology and the conservation of all of the recognised catalytic motifs [PMID: 7966317] (although the first motif is unusual in the replacement of the more common aspartate with glycine). The variable domain is found in between motifs 1 and 2, indicating membership in subfamily I and phylogeny and prediction of the alpha helical nature of the variable domain indicate membership in subfamily IA.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
TIGRFAMs