RfaE bifunctional protein, domain I (IPR011913)

Short name: RfaE_dom_I

Overlapping homologous superfamilies

Domain relationships


RfaE is a protein involved in the biosynthesis of ADP-L-glycero-D-manno-heptose, a precursor for LPS inner core biosynthesis. RfaE is a bifunctional protein in Escherichia coli, and separate proteins in some other genome. The longer, N-terminal domain I (this family) is suggested to act in D-glycero-D-manno-heptose 1-phosphate biosynthesis, while domain II (IPR011914) adds ADP to yield ADP-D-glycero-D-manno-heptose [PMID: 10629197].

GO terms

Biological Process

GO:0005975 carbohydrate metabolic process

Molecular Function

GO:0016779 nucleotidyltransferase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.