Family

Isopentenyl-diphosphate delta-isomerase, type 1 (IPR011876)

Short name: IsopentenylPP_isomerase_typ1

Family relationships

None.

Description

This entry represents type 1 of two non-homologous families of the enzyme isopentenyl-diphosphate delta-isomerase (IPP isomerase; EC:5.3.3.2). IPP isomerase is a member of the Nudix hydrolase superfamily, and is a key enzyme in the isoprenoid biosynthetic pathway. It catalyses the interconversion of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate. Dimethylallyl phosphate is the initial substrate for the biosynthesis of carotenoids and other long chain isoprenoids [PMID: 9736763]. IPP is an essential building block for many compounds, including enzyme cofactors, sterols, and prenyl groups. This enzyme interconverts isopentenyl diphosphate and dimethylallyl diphosphate. The enzyme requires one Mn2+ or Mg2+ ion in its active site to fold into an active conformation and also contains the Nudix motif, a highly conserved 23-residue block (GX5EX7REUXEEXGU, where U = I, L or V), that functions as a metal binding and catalytic site. The metal binding site is present within the active site and plays structural and catalytical roles. IPP isomerase is well represented in several bacteria, archaebacteria and eukaryotes, including fungi, mammals and plants. Despite sequence variations (mainly at the N terminus), the core structure is highly conserved [PMID: 9418296].

GO terms

Biological Process

GO:0008299 isoprenoid biosynthetic process

Molecular Function

GO:0004452 isopentenyl-diphosphate delta-isomerase activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PANTHER
CDD
PIRSF
HAMAP
TIGRFAMs