Homocitrate synthase, fungi/archaea (IPR011872)
Short name: Homocitrate_synth_fun/arc
Overlapping homologous superfamilies
- Aldolase-type TIM barrel (IPR013785)
This entry includes the yeast LYS21 gene which carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway [PMID: 16299000, PMID: 9099739]. A related pathway is found in Thermus thermophilus [PMID: 10613839]. This enzyme is closely related to 2-isopropylmalate synthase (LeuA) and citramalate synthase (CimA), both of which are present in the euryarchaeota. Some archaea have a separate homocitrate synthase (AksA) which also synthesizes longer homocitrate analogs [PMID: 9665716].
No terms assigned in this category.
- TIGR02146 (LysS_fung_arch)