Homocitrate synthase, fungi/archaea (IPR011872)

Short name: Homocitrate_synth_fun/arc

Overlapping homologous superfamilies

Family relationships



This entry includes the yeast LYS21 gene which carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway [PMID: 16299000, PMID: 9099739]. A related pathway is found in Thermus thermophilus [PMID: 10613839]. This enzyme is closely related to 2-isopropylmalate synthase (LeuA) and citramalate synthase (CimA), both of which are present in the euryarchaeota. Some archaea have a separate homocitrate synthase (AksA) which also synthesizes longer homocitrate analogs [PMID: 9665716].

GO terms

Biological Process

GO:0019752 carboxylic acid metabolic process
GO:0019878 lysine biosynthetic process via aminoadipic acid

Molecular Function

GO:0004410 homocitrate synthase activity
GO:0046912 transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.