O-succinylhomoserine (thiol)-lyase (IPR011821)

Short name: O_succ_thio_ly

Overlapping homologous superfamilies

Family relationships


This family consists of O-succinylhomoserine (thiol)-lyase, one of three different enzymes designated cystathionine gamma-synthase and involved in methionine biosynthesis. In all three cases, sulphur is added by transsulphuration from Cys to yield cystathionine rather than by a sulphhydrylation step that uses H2S directly and bypasses cystathionine.

The CGS enzyme (P00935) from Escherichia coli is, like other CGS enzymes, a homotetramer composed of two catalytically active dimers [PMID: 9843488]. The active site of each dimer is found at the interface between the monomers and involves residues from each monomer. Catalysis occurs by alpha,gamma-elimination/replacement reactions.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.