Cd(II)/Pb(II)-responsive transcriptional regulator (IPR011791)

Short name: CadR-PbrR

Overlapping homologous superfamilies

Family relationships



This entry represents the cadmium(II) and/or lead(II) responsive transcriptional activator of the proteobacterial metal efflux system [PMID: 11282588, PMID: 11544228]. This protein contains a distinctive pattern of cysteine residues in its metal binding loop, Cys-X(6-9)-Cys, as well as a conserved and critical cysteine at the N-terminal end of the dimerization helix [PMID: 12958362].

Pseudomonas aeruginosa CadR and Ralstonia metallidurans PbrR that regulate expression of the cadmium and lead resistance operons, are comprised of distinct domains that harbour the regulatory (effector-binding) site and the active (DNA-binding) site [PMID: 12901859]. Their conserved N-terminal domains contain predicted winged helix-turn-helix motifs that mediate DNA binding, while the C-terminal domains have the three conserved cysteines which form a putative metal binding site. Some members in this group have a histidine-rich C-terminal extension. These proteins share the N-terminal DNA binding domain with other transcription regulators of the MerR superfamily that promote transcription by reconfiguring the spacer between the -35 and -10 promoter elements [PMID: 12829265].

GO terms

Biological Process

GO:0045893 positive regulation of transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0046872 metal ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.