Cu(I)-responsive transcriptional regulator (IPR011789)

Short name: CueR

Overlapping homologous superfamilies

Family relationships



This entry represents the copper-, silver- and gold- (I) responsive transcriptional activator of the gamma proteobacterial copper efflux system [PMID: 11136469]. This protein is a member of the MerR family of transcriptional activators and contains a distinctive pattern of cysteine residues in its metal binding loop, Cys-X7-Cys. This family also lacks a conserved cysteine at the N-terminal end of the dimerization helix which is required for the binding of divalent metals such as zinc; here it is replaced by a serine residue [PMID: 12958362].

GO terms

Biological Process

GO:0045893 positive regulation of transcription, DNA-templated

Molecular Function

GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0005507 copper ion binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.