Hydantoinase/dihydropyrimidinase (IPR011778)

Short name: Hydantoinase/dihydroPyrase

Overlapping homologous superfamilies

Family relationships


Dihydropyrimidinase (DHPase) catalyses the second step of the reductive pyrimidine degradation, the reversible hydrolytic ring opening of dihydropyrimidines [PMID: 12626710]. Primarily converts 5,6-dihydrouracil to N-carbamyl-beta-alanine (also called 3-ureidopropanoate) but also acts on dihydrothymine and hydantoin. The enzyme is a metalloenzyme [PMID: 7765480].

This entry represents the hydantoinase/dihydropyrimidinase family, which also includes D-phenylhydantoinases. This enzyme catalyses the stereospecific hydrolysis of the cyclic amide bond of D-hydantoin derivatives with an aromatic side chains at the 5'-position, and has no activity on dihydropyrimidines [PMID: 11092864].

Dihydropyrimidinase-related proteins (collapsin response mediator proteins, CRMPs) share sequence similarity with liver DHPase. Although purified CRMP does not hydrolyse DHPase substrates, it is likely that a related activity accounts for its participation in neuronal growth cone signaling [PMID: 9375656]. CRMP3 has histone H4 deacetylase activity [PMID: 23443259].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005737 cytoplasm

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.