Tyrosine aminotransferase ubiquitination region (IPR011715)

Short name: Tyr_aminoTrfase_ubiquitination

Overlapping homologous superfamilies


Domain relationships



This region contains a probable site of ubiquitination that ensures rapid degradation of tyrosine aminotransferase in rats. The half life of the enzyme in vivo is about 2-4 hours. The enzyme contains at least 2 phosphorylation sites including CAPK at Ser29 and, at the other end of the protein, a casein kinase II site at S*QEECDK. This region of TAT is probably primarily related to regulatory events. Most other transaminases are much more stable and are not phosphorylated.

GO terms

Biological Process

GO:0009074 aromatic amino acid family catabolic process

Molecular Function

GO:0004838 L-tyrosine:2-oxoglutarate aminotransferase activity
GO:0030170 pyridoxal phosphate binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.