Domain

LETM1-like (IPR011685)

Short name: LETM1

Domain relationships

None.

Description

This is a group of mainly hypothetical eukaryotic proteins. Putative features found in LETM1, such as a transmembrane domain and a CK2 and PKC phosphorylation site [PMID: 10486213], are relatively conserved throughout the family. Deletion of LETM1 is thought to be involved in the development of Wolf-Hirschhorn syndrome in humans [PMID: 10486213]. A member of this family, P91927, is known to be expressed in the mitochondria of Drosophila melanogaster [PMID: 10071211], suggesting that this may be a group of mitochondrial proteins.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam