GcrA cell cycle regulator (IPR011681)

Short name: GcrA

Overlapping homologous superfamilies


Family relationships



GcrA, together with CtrA (see IPR001789 and IPR001867), form a master cell cycle regulator. These bacterial regulators are involved in controlling the progression and asymmetric polar morphogenesis [PMID: 15087506]. During this process, there are temporal and spatial variations in the concentrations of GcrA and CtrA. The variation in concentration produces time and space dependent transcriptional regulation of modular functions that implement cell-cycle processes [PMID: 15087506]. More specifically, GcrA acts as an activator of components of the replisome and the segregation machinery [PMID: 15087506].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.