Brf1, TBP-binding domain (IPR011665)

Short name: BRF1_TBP-bd_dom

Overlapping homologous superfamilies


Domain relationships



In budding yeasts, Brf1 forms the TFIIIB complex with TATA-binding protein (TBP) and Bdp1 [PMID: 24336746]. The TFIIIB complex can be recruited to the Pol III promoters and form an exceptionally kinetically stable TFIIIB-DNA complex, which then recruits the Pol III enzymatic complex and helps maintain it for multiple transcription cycles in a process called facilitated recycling [PMID: 24277937].

This entry represents the TATA binding protein (TBP) binding domain of Brf1 that covers both the Brf homology II and III regions [PMID: 12660736].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.