Domain

KAP family P-loop domain (IPR011646)

Short name: KAP_P-loop

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

The KAP (after Kidins220/ARMS and PifA) family of predicted NTPases are sporadically distributed across a wide phylogenetic range in bacteria and in animals. Many of the prokaryotic KAP NTPases are encoded in plasmids and tend to undergo disruption to form pseudogenes. A unique feature of all eukaryotic and certain bacterial KAP NTPases is the presence of two or four transmembrane helices inserted into the P-loop NTPase domain. These transmembrane helices anchor KAP NTPases in the membrane such that the P-loop domain is located on the intracellular side [PMID: 15128444].

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam