Domain

Heme NO-binding (IPR011644)

Short name: Heme_NO-bd

Overlapping homologous superfamilies

Domain relationships

None.

Description

The HNOB (Haem NO Binding) domain is a predominantly alpha-helical domain and binds heme via a covalent linkage to histidine [PMID: 12590654]. This domain is found in soluble guanylate cyclases, which are nitric oxide-responsive signaling proteins. It is predicted to function as a haem-dependent sensor for gaseous ligands and to transduce diverse downstream signals in both bacteria and animals. In Clostridium botulinum displays femtomolar affinity for nitrous oxide (NO) [PMID: 15472039].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0020037 heme binding

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam