Domain

Nucleoside transporter/FeoB GTPase, Gate domain (IPR011642)

Short name: Gate_dom

Domain relationships

None.

Description

This domain is responsible for determining nucleoside specificity in the human sodium/nucleoside cotransporter proteins CNT1 and CNT2 (e.g. O00337) [PMID: 10455109]. In the FeoB proteins (e.g. O25396), which are believed to be Fe2+ transporters, it includes the membrane pore region, so the function of this domain is likely to be more general than just nucleoside specificity [PMID: 12781516]. It may represent the pore and gate, with a wide potential range of specificity. Hence its name - Gate.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam