Domain

Alpha-macroglobulin-like, TED domain (IPR011626)

Short name: Alpha-macroglobulin_TED

Overlapping homologous superfamilies

Domain relationships

Description

This entry corresponds to the TED domain of the complement components such as C3, C4 and C5. This domain contains a short highly conserved region of proteinase-binding alpha-macro-globulins contains the cysteine and a glutamine of a thiol-ester bond that is cleaved at the moment of proteinase binding, and mediates the covalent binding of the alpha-macro-globulin to the proteinase. The GCGEQ motif is highly conserved [PMID: 10625650, PMID: 11106161, PMID: 11387479, PMID: 10825534].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0005615 extracellular space

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam