Homologous Superfamily

T7 endonuclease I-like (IPR011578)

Short name: T7_endonucI-like

Overlapping entries


This superfamily represents a domain found in FokI and other restriction endonucleases, as well as in bacteriophage endonucleases I (Holliday junction resolvase). FokI recognises the double-stranded DNA sequence 5'-GGATG-3' and cleaves DNA phosphodiester groups 9 base pairs away on this strand and 13 base pairs away on the complementary strand [PMID: 12093751]. Endonuclease I (EC: is a junction-resolving enzyme encoded by Bacteriophage T7, that selectively binds and cleaves four-way Holliday DNA junctions [PMID: 12093751]. The structure of the enzyme shows that it forms a symmetric homodimer arranged in two well-separated domains. Each domain, however, is composed of elements from both subunits, and amino acid side chains from both protomers contribute to the active site [PMID: 11135673].

GO terms

Biological Process

No terms assigned in this category.

Molecular Function

GO:0003677 DNA binding
GO:0004536 deoxyribonuclease activity

Cellular Component

No terms assigned in this category.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.