Domain

SLC26A/SulP transporter domain (IPR011547)

Short name: SLC26A/SulP_dom

Domain relationships

None.

Description

This entry represents a conserved domain found in a group of sulphate transporters, known as the SLC26A/SulP family [PMID: 8140616, PMID: 7616962]. These proteins contain an N-terminal membrane domain and a C-terminal cytoplasmic STAS domain a STAS (sulfate transporter and anti-sigma factor antagonist) domain [PMID: 10662676]. This central domain is usually found next to the STAS domain (IPR002645). Proteins containing this domain include:

  • Neurospora crassa sulphate permease II (gene cys-14).
  • Yeast sulphate permeases (genes SUL1 and SUL2).
  • Rat sulphate anion transporter 1 (SAT-1).
  • Mammalian DTDST, a probable sulphate transporter which, in human, is involved in the genetic disease, diastrophic dysplasia (DTD).
  • Sulphate transporters 1, 2 and 3 from the legume Stylosanthes hamata.
  • Human pendrin (gene PDS), which is involved in a number of hearing loss genetic diseases.
  • Human protein DRA (Down-Regulated in Adenoma).
  • Soybean early nodulin 70.
  • Escherichia coli hypothetical protein ychM.
  • Caenorhabditis elegans hypothetical protein F41D9.5.

GO terms

Biological Process

GO:0008272 sulfate transport

Molecular Function

GO:0015116 sulfate transmembrane transporter activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
Pfam