Nickel/cobalt transporter, high-affinity (IPR011541)

Short name: Ni/Co_transpt_high_affinity

Overlapping homologous superfamilies


Family relationships


High affinity nickel transporters are involved in the incorporation of nickel into H2-uptake hydrogenase [PMID: 7934894, PMID: 7651142] and urease [PMID: 8197192] enzymes and are essential for the expression of catalytically active hydrogenase and urease. Ion uptake is dependent on proton motive force. HoxN in Ralstonia eutropha (Alcaligenes eutrophus) is thought to be an integral membrane protein with seven transmembrane helices [PMID: 8288539]. The transporter RcnA has been implicated in Ni(II) and Co(II) detoxification in E. coli, probably through efflux [PMID: 17120142].

GO terms

Biological Process

GO:0035444 nickel cation transmembrane transport

Molecular Function

GO:0046872 metal ion binding
GO:0015099 nickel cation transmembrane transporter activity

Cellular Component

GO:0016021 integral component of membrane

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.