Non-structural maintenance of chromosomes element 1 (IPR011513)

Short name: Nse1

Overlapping homologous superfamilies

Family relationships



Saccharomyces cerevisiae Nse1 (Q07913) forms part of a complex with SMC5-SMC6. This non-structural maintenance of chromosomes (SMC) complex plays an essential role in genomic stability, being involved in DNA repair and DNA metabolism [PMID: 12966087, PMID: 11927594]. It is conserved in eukaryotes from yeast to human. Nse1 acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. It also functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks [PMID: 11927594, PMID: 12966087].

GO terms

Biological Process

GO:0006281 DNA repair

Molecular Function

No terms assigned in this category.

Cellular Component

GO:0030915 Smc5-Smc6 complex

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.