Domain

BCNT-C domain (IPR011421)

Short name: BCNT-C

Overlapping homologous superfamilies

None.

Domain relationships

None.

Description

Vertebrate BCNT (named after Bucentaur) protein is found in the nucleus and cytosol. Gene duplication of the ancestral BCNT gene leads to the h-type BCNT or craniofacial development protein 1 (CFDP1) gene and the ruminant-specific p97BCNT or craniofacial development protein 2 (CFDP2) gene. The h-type BCNT proteins contain a highly conserved 82-amino acid region at the C terminus (BCNT-C) that is not present in p97BCNT. Instead ruminant p97BCNT contains a region derived from the endonuclease domain of a retrotransposable element RTE-1 [PMID: 12832649, PMID: 16384818].

In addition to h-type BCNT proteins, a BCNT-C domain is also found in Drosophila YETI, a protein that binds to a microtubule-based motor kinesin-1, and the yeast SWR1-complex protein 5 (SWC5) or AOR1 (actin overexpression resistant 1), a component of the SWR1 chromatin remodeling complex [PMID: 16384818, PMID: 14720462].

The entry represents the entire BCNT-C domain.

Contributing signatures

Signatures from InterPro member databases are used to construct an entry.
PROSITE profiles
Pfam